Table 3. SIRs for GI cancers after lower GI bleeding (n=58,593), by follow-up period and patient characteristics.
|
Total follow-up |
<1 year |
1–<5 years |
5+ years |
|||||
|---|---|---|---|---|---|---|---|---|
| O | SIR (95% CI) | O | SIR (95% CI) | O | SIR (95% CI) | O | SIR (95% CI) | |
| All GI cancers | 2806 | 3.94 (3.79–4.08) | 2098 | 16.3 (15.6–17.0) | 491 | 1.36 (1.25–1.49) | 217 | 0.97 (0.84–1.10) |
| Sex | ||||||||
| Women | 1208 | 3.65 (3.45–3.86) | 874 | 14.8 (13.8–15.8) | 225 | 1.34 (1.17–1.53) | 109 | 1.04 (0.86–1.26) |
| Men | 1598 | 4.18 (3.98–4.39) | 1224 | 17.6 (16.6–18.6) | 266 | 1.38 (1.22–1.56) | 108 | 0.90 (0.74–1.09) |
| Age | ||||||||
| 0–49 years | 128 | 4.01 (3.35–4.77) | 79 | 26.1 (20.6–32.5) | 27 | 2.04 (1.34–2.96) | 22 | 1.41 (0.88–2.14) |
| 50–69 years | 1086 | 3.80 (3.57–4.03) | 806 | 21.2 (19.7–22.7) | 169 | 1.26 (1.08–1.46) | 111 | 0.98 (0.80–1.18) |
| 70+ years | 1592 | 4.03 (3.84–4.23) | 1213 | 13.9 (13.1–14.7) | 295 | 1.39 (1.24–1.56) | 84 | 0.88 (0.70–1.09) |
| Calendar year | ||||||||
| 1995–2000 | 741 | 2.91 (2.70–3.13) | 472 | 14.4 (13.1–15.7) | 160 | 1.46 (1.25–1.71) | 109 | 0.97 (0.79–1.17) |
| 2001–2006 | 1264 | 3.60 (3.40–3.80) | 914 | 17.0 (15.9–18.2) | 242 | 1.30 (1.14–1.48) | 108 | 0.97 (0.79–1.17) |
| 2007–2011 | 801 | 7.47 (6.97–8.01) | 712 | 16.9 (15.7–18.2) | 89 | 1.37 (1.10–1.68) | 0 | — |
| Place of diagnosis | ||||||||
| Emergency room | 303 | 5.97 (5.32–6.69) | 241 | 24.9 (21.9–28.3) | 42 | 1.69 (1.22–2.28) | 20 | 1.24 (0.75–1.91) |
| Inpatient unit | 1448 | 3.95 (3.75–4.16) | 1044 | 14.6 (13.7–15.5) | 296 | 1.61 (1.43–1.80) | 108 | 0.97 (0.80–1.18) |
| Outpatient clinic | 1055 | 3.57 (3.36–3.79) | 813 | 17.1 (16.0–18.4) | 153 | 1.02 (0.86–1.19) | 89 | 0.91 (0.73–1.13) |
| Type of diagnosis | ||||||||
| Primary | 2448 | 3.82 (3.67–3.97) | 1816 | 15.9 (15.1–16.6) | 434 | 1.34 (1.22–1.47) | 198 | 0.97 (0.84–1.12) |
| Secondary | 358 | 5.02 (4.51–5.57) | 282 | 19.9 (17.7–22.4) | 57 | 1.58 (1.20–2.05) | 19 | 0.90 (0.54–1.41) |
| Adenomas | ||||||||
| No | 2331 | 3.85 (3.69–4.01) | 1753 | 16.20 (15.5–17.0) | 394 | 1.30 (1.17–1.43) | 184 | 0.95 (0.82–1.10) |
| Yes | 475 | 4.44 (4.05–4.85) | 345 | 16.9 (15.1–18.7) | 97 | 1.74 (1.41–2.12) | 33 | 1.07 (0.74–1.51) |
| Charlson scorea | ||||||||
| Low (0) | 1527 | 3.69 (3.51–3.88) | 1163 | 18.8 (17.7–19.9) | 234 | 1.16 (1.02–1.32) | 130 | 0.86 (0.72–1.02) |
| Medium (1–2) | 984 | 4.10 (3.85–4.36) | 708 | 14.2 (13.2–15.3) | 204 | 1.61 (1.40–1.85) | 72 | 1.13 (0.88–1.42) |
| High (3+) | 295 | 4.99 (4.44–5.59) | 227 | 13.3 (11.6–15.2) | 53 | 1.64 (1.23–2.14) | 15 | 1.55 (0.87–2.55) |
| Alcoholism-related disease | ||||||||
| No | 2669 | 3.86 (3.71–4.01) | 2004 | 16.1 (15.4–16.9) | 461 | 1.32 (1.20–1.45) | 204 | 0.93 (0.81–1.07) |
| Yes | 137 | 6.48 (5.44–7.67) | 94 | 20.9 (16.9–25.6) | 30 | 2.74 (1.85–3.92) | 13 | 2.28 (1.21–3.90) |
CI, confidence interval; GI, gastrointestinal; O, observed number of patients; SIR, standardized incidence ratio.
a
According to the Charlson Comorbidity Index.