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. 2016 May 4;6:25187. doi: 10.1038/srep25187

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Copyright © 2016, Macmillan Publishers Limited

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(A) Albumin secretion normalized to spheroid volumes during long-term spheroid culture (n = 15 spheroids from 3 donors per time point). (B) CYP-dependent metabolic activity of PHH spheroids over 35 days. PHH spheroids were exposed to a cocktail of 5 CYP substrates and the resulting metabolites were analysed via LC-MS/MS (n = 8 spheroids per time point). No changes in rate of drug metabolism were detected for CYP1A2, CYP2D6 and CYP3A4 over the course of 5 weeks (n.s. corresponds to p > 0.05, F-test), whereas CYP2C8 and CYP2C9 activities were found to be significantly decreased (p < 0.001) or increased (p < 0.05) respectively.