Table 2. The GO and KEGG pathway analyses of the genes commonly up-regulated by both 5-Aza-CdR treatment and Dnmt1-knockdown.

Term	Description	Genes	NGR	NG	p-value
GO:0009615	Response to virus	Klra8,Zc3hav1,Ifih1,Irf7,Oas1b,Rsad2,Ifit1,Mx2	79 (36814)	8 (105)	2.36441E-08
GO:0035458	Cellular response to interferon-beta	Gbp3,Gbp2,Ifit3,Ifit1	17 (36814)	4 (105)	2.31915E-05
GO:0006955	Immune response	B2m,Oasl2,Oas1b,Ccl2,Oas1a,Ccl5	151 (36814)	6 (105)	0.00053118
GO:0071346	Cellular response to interferon-gamma	Gbp3,Gbp2,Ccl2	16 (36814)	3 (105)	0.000986171
GO:0019060	Intracellular transport of viral proteins in host cell	Tap1,Ifit1	4 (36814)	2 (105)	0.00309224
GO:0043123	Positive regulation of I-kappaB kinase/NF-kappaB cascade	Bst2,Rnf31,Zc3hav1,Ubd	98 (36814)	4 (105)	0.00535993
GO:0010759	Positive regulation of macrophage chemotaxis	Ccl2,Ccl5	7 (36814)	2 (105)	0.00538121
GO:0045071	Negative regulation of viral genome replication	Ifit1,Ccl5	7 (36814)	2 (105)	0.00538121
GO:0071360	Cellular response to exogenous dsRNA	Zc3hav1,Ifit1	7 (36814)	2 (105)	0.00538121
GO:0032020	ISG15-protein conjugation	Ube2l6,Usp18	6 (36814)	2 (105)	0.00550129
Pathway
KEGG 05162	Measles	Mx2,Adar,Irf7,Stat2,Oas1a,Ifih1,Oas2,Oas1b	135 (36814)	8 (105)	2.85178E-07
KEGG 05160	Hepatitis C	Irf7,Stat2,Ifit1,Oas1a,Oas2,Oas1b	137 (36814)	6 (105)	7.35785E-05
KEGG 04623	Cytosolic DNA-sensing pathway	Ccl5,Adar,Irf7	62 (36814)	3 (105)	0.0130779
KEGG 04620	Toll-like receptor signaling pathway	Ccl5,Irf7,Cd80	100 (36814)	3 (105)	0.0387771

The top 10 terms of GO analysis of the genes commonly up-regulated by both 5-Aza-CdR treatment and Dnmt1-knockdown.

The KEGG Pathway analysis of the genes commonly up-regulated by both 5-Aza-CdR treatment and Dnmt1-knockdown.

GO, gene ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; NGR, Number of annotated genes in the reference list (Total number of genes in the reference list); NG, Number of annotated genes in the input list (Total number of genes in the input list).