Fig. 7.
Minimal effects of Tph2 knockout on ventilation at rest or during hypoxia in adult rats. Ventilation (V̇e; ml·min−1·100 g−1; A), breathing frequency (breaths/min; B), V̇e [expressed as a percentage of room air breathing, (%control); C], and tidal volume (VT; ml·breath−1·100 g−1; D) were compared among control (WT and Het) and DATph2−/− adult rats. Breathing frequency was significantly lower and VT higher in DATph2−/− rats compared with controls when exposed to either RA or 12% O2. *Significant effect of genotype (P < 0.05; 2-way RM ANOVA).