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Tph2 knockout rats maintain body temperature during a cold challenge. Rectal temperature (TR; °C) was measured 30 min before (room temperature; 23°C) and at 30-min intervals for up to 4 h while exposed to an ambient temperature of 4°C. Note that control (WT and Het) and DATph2−/− rats both maintain body temperature during environmental cooling (P > 0.05, two-way ANOVA).
