Table 1.
microRNA specifically and significantly altered temporally during macrophage polarization
| All Time Points and Conditions |
Across Conditions at Relevant Time Point |
|||||
|---|---|---|---|---|---|---|
| Condition | microRNA | Overall P Value | FDR | Time Point, h | P Value | FDR |
| M1 related | mmu-miR-155 | 8.3E-09 | 7.2E-08 | 1 | 0.08 | 0.53 |
| 3 | 1.8E-04 | 2.5E-03 | ||||
| 24 | 7.4E-09 | 3.9E-07 | ||||
| mmu-miR-125a-3p | 1.3E-04 | 6.2E-04 | 3 | 2.9E-04 | 3.6E-03 | |
| 24 | 2.1E-04 | 2.4E-03 | ||||
| mmu-miR-147 | 2.4E-04 | 0.01 | 3 | 2.0E-03 | 0.02 | |
| 24 | 2.7E-05 | 4.4E-04 | ||||
| mmu-miR-199a-3p | 0.01 | 0.05 | 3 | 0.08 | 0.44 | |
| 24 | 5.3E-03 | 0.03 | ||||
| mmu-miR-214-3p | 6.4E-03 | 0.02 | 3 | 0.03 | 0.18 | |
| 24 | 9.9E-04 | 7.3E-03 | ||||
| mmu-miR-455-5p | 0.01 | 0.04 | 3 | 3.5E-03 | 0.03 | |
| 24 | 0.05 | 0.18 | ||||
| mmu-miR-125a-5p | 2.5E-03 | 0.01 | 24 | 4.6E-04 | 3.9E-03 | |
| mmu-miR-21# | 8.8E-05 | 4.4E-04 | 3.5E-04 | 3.5E-03 | ||
| mmu-miR-210 | 4.5E-07 | 3.0E-06 | 4.0E-04 | 3.9E-03 | ||
| mmu-miR-489 | 4.8E-12 | 5.8E-11 | 1.5E-05 | 2.9E-04 | ||
| M2a related | mmu-miR-511 | 8.0E-05 | 4.0E-04 | 1 | 0.02 | 0.16 |
| 3 | 4.1E-04 | 4.8E-03 | ||||
| mmu-miR-449a | 3.6E-03 | 0.01 | 24 | 3.4E-04 | 3.5E-03 | |
microRNAs (miRNA or miR) that were specifically up- or downregulated (≥2-fold) relative to the 0 h time point in only 1 stimulating condition [M1 (IFN-γ + LPS) or M2a (IL-4)] and were statistically significant across 3 biological replicates/time point/condition. The miRNAs chosen for this dataset must have an overall P value ≤0.05 and false discovery rate (FDR) of ≤0.05. Additionally, miRNAs in this dataset must have exhibited a P value ≤0.05 and FDR ≤0.05 when compared with the other stimulating conditons in at least 1 time point.