Table 2. Characteristics of psychosis and measurements of IgG antibodies to the N-methyl-D-aspartate receptor (NMDAR) in 10 patients with narcolepsy type 1 comorbid with psychosis.

	Case 1 S-925 Spain	Case 2 NUR-055 Spain	Case 3 S-462 Spain	Case 4 S-412 Spain	Case 5 WG France	Case 6 CT France	Case 7 LG France	Case 8 MR France	Case 9 JM France	Case 10 NY France
Auditory hallucinations	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Psychiatric hospitalization required	Yes, 24 days	Yes, 1 month	No	No	No	Yes, 2 weeks	Yes, several months	Yes, 3 weeks	No	Yes, several months
Age at onset of first psychosis episode	15 (a few months before narcolepsy)	27 (19 years after narcolepsy)	17 (at sleepiness onset)	7 (at sleepiness onset)	39 (24 years after narcolepsy)	47 (21 years after narcolepsy)	45 (12 years after narcolepsy)	23 (13 years after narcolepsy)	30 (1 year after sleepiness onset but few weeks after modafinil)	22 (10 years after narcolepsy)
Triggering factors	No	No	No But worsening after modafinil	No But worsening after sodium oxybate	Heroin and cocaine abuse	Sodium Oxybate	Mazindol	Cannabis	Modafinil and then methylphenidate	No
Medications for psychiatric symptoms	Clozapine 150 mg/d	Aripiprazole 30 mg/d	Risperidone 3 mg/d Ziprasidone 80 mg/d	Olanzapine 15 mg/d Fluoxetine 20 mg for compulsive eating	Methadone 130 mg/d	Alimemazine 15 mg/d	Olanzapine 15 mg/d	Aripiprazole 15 mg/d	No drugs	Aripiprazole 20 mg/d
IgG antibodies to NMDA receptor	Negative (CSF)	Negative (serum)	Negative (CSF)	Negative (serum)	Negative (serum)	Negative (serum)	Negative (serum)	Negative (serum)	Negative (serum)	na