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. 2016 Apr 8;6(4):e412. doi: 10.1038/bcj.2016.11

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(a) G-banded karyogram from the diagnostic bone marrow showing the rearrangement between the long arm of chromosome 8 and short arm of chromosome 12 (arrowed), with an extra copy of the derivative chromosome 8, International System for Human Cytogenetic Nomenclature (ISCN) karyotype refined as: 46,XY,der(8)inv(q12.1q21.1)t(8;12)(q12.1;p13),der(12)t(8;12)(q12.1;p13)[2]/47,sl,+der(8)inv(8)t(8;12)[5]/48,sdl1,+der(8)inv(8)t(8;12)[2]/46,XY[2]. Fluorescence in situ hybridisation (FISH) with ETV6 break apart gene probes showing split red and green signals, and extra red signal from the duplicated der(8) in interphase cell nuclei from the bone marrow aspirate (b) and on the paraffin-embedded tissue section from the lymph node biopsy (c).