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. 2016 Apr 25;6(4):e204. doi: 10.1038/nutd.2016.10

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Copyright © 2016 Macmillan Publishers Limited

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(a) In silico analysis using MetaCore showed that inflammation_IL-6 signalling was significantly enriched in the differentially expressed proteins of the HFD groups compared with control (FDR-corrected P-value=6.5E-6). Analysed proteins are denoted with a circle (red=upregulation, blue=downregulation). (b) Gene ontology analysis using BiNGO confirmed that acute and chronic inflammatory responses are significantly enriched in the differentially expressed hypothalamic proteins of HFD-fed mice compared with control. Coloured nodes representing GO terms correspond to those that were significant according to the P-value colour scale, whereas white nodes were not significant. The size of the node reflects the number of proteins that mapped to the corresponding GO term.