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. 2016 Apr 29;5(4):e77. doi: 10.1038/cti.2016.13

Table 2. Lists of investigations on changes in biomarker levels in postoperative venous blood following major surgery.

Biomarker type Biomarker name No. of investigations
Total no. of studies
    Postoperative changes (1 day) Also see Supplementary Table S2
 
    Decrease No change Increase ND  
Pro-inflammatory cytokines IL-1β 3 21 3 5 32
  IL-2 7 4 1 1 13
  IL-6 87 1 88
  IL-12 2 5 1 8
  IL-17 1 1 2
  IFN-γ 1 6 7
  TNF-α 5 23 6 5 39
  IL-22 1 1
Anti-inflammatory cytokines IL-4 1 4 2 7
  IL-5 2 2 4
  IL-10 12 28 40
  IL-13 4 4
  IL-1RA 3 8 11
Chemokines IL-8 7 31 2 40
  MCP-1 7 2 9
  MIP-1α 1 1 2
DAMPs HMGB-1 1 5 6
  HSP-27 1 1
  HSP-60 1 1
  HSP-70 2 2
Others sIL-6R 1 1
  sCD-14 3 3

Abbreviations: DAMP, damage-associated molecular pattern; IL, interleukin; IL-1RA, IL-1 receptor antagonist; ND, not detectable; sCD-14, soluble CD-14; sIL-6R, soluble IL-6 receptor; TNF, tumor necrosis factor.