Table 2. Lists of investigations on changes in biomarker levels in postoperative venous blood following major surgery.
Biomarker type | Biomarker name |
No. of investigations |
Total no. of studies | |||
---|---|---|---|---|---|---|
Postoperative changes (1 day) Also see
Supplementary Table S2 |
||||||
Decrease | No change | Increase | ND | |||
Pro-inflammatory cytokines | IL-1β | 3 | 21 | 3 | 5 | 32 |
IL-2 | 7 | 4 | 1 | 1 | 13 | |
IL-6 | — | — | 87 | 1 | 88 | |
IL-12 | 2 | 5 | 1 | — | 8 | |
IL-17 | — | 1 | — | 1 | 2 | |
IFN-γ | 1 | 6 | — | — | 7 | |
TNF-α | 5 | 23 | 6 | 5 | 39 | |
IL-22 | — | — | 1 | — | 1 | |
Anti-inflammatory cytokines | IL-4 | 1 | 4 | 2 | — | 7 |
IL-5 | — | 2 | 2 | — | 4 | |
IL-10 | — | 12 | 28 | — | 40 | |
IL-13 | — | 4 | — | — | 4 | |
IL-1RA | — | 3 | 8 | — | 11 | |
Chemokines | IL-8 | — | 7 | 31 | 2 | 40 |
MCP-1 | — | 7 | 2 | — | 9 | |
MIP-1α | 1 | 1 | — | — | 2 | |
DAMPs | HMGB-1 | — | 1 | 5 | — | 6 |
HSP-27 | — | 1 | — | — | 1 | |
HSP-60 | 1 | — | — | — | 1 | |
HSP-70 | — | 2 | — | — | 2 | |
Others | sIL-6R | 1 | — | — | — | 1 |
sCD-14 | — | — | 3 | — | 3 |
Abbreviations: DAMP, damage-associated molecular pattern; IL, interleukin; IL-1RA, IL-1 receptor antagonist; ND, not detectable; sCD-14, soluble CD-14; sIL-6R, soluble IL-6 receptor; TNF, tumor necrosis factor.