Figure 5. 17R-RvD1 treatments modulate the local production of bioactive lipid mediators within inflamed paws.

Arthritic mice were treated daily with vehicle (0.1% ethanol) or 17R-RvD1 (100 ng), and paws were collected for metabololipidomics analysis on day 8; naive mice were used as controls. (A) Relative abundance of key arachidonic acid–derived leukotrienes and prostanoids. Representative mass spectrum of (B) LTB₄ and PGE₂ within arthritic paws. (C) Absolute quantification of lipid mediator levels in arthritic paws identified using scheduled multiple reaction monitoring (MRM). n = 5–7 per group. *P < 0.05 and ***P < 0.001 vs. naive and ^#P < 0.05 vs. arthritis with 1-way ANOVA and Bonferroni post-hoc test.