Table 2.
Gene onthology of the TM/C DE genes
| Gene name | Molecular function | Fold Change |
|---|---|---|
| Energy metabolism | ||
| MRPL28 | Mitochondrial ribosomal protein encoded by the nucleus which helps in protein synthesis within the mitochondrion | 0.78 |
| COQ6 | Monooxygenase required for the biosynthesis of coenzyme Q10. | 0.84 |
| MCAT | Enzyme which catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. | 0.85 |
| TBL1X | Corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. | 1.28 |
| ACP6 | Phosphatase which regulates lipid metabolism in mitochondria. | 0.81 |
| CYP39A1 | Monooxygenase, which catalyzes many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. | 0.84 |
| Cell proliferation and vascularization pathway | ||
| BTC | Ligand for the EGF receptor, regulation cell growth and differentiation. | 1.22 |
| ABHD2 | Protein specifically expressed in mouse vascular muscle cells and not in skeletal muscle cells. | 1.24 |
| EPS15 | Protein involved in EGFR pathway. | 1.24 |
| Muscle growth | ||
| MBNL2 | C3H-type zinc finger protein that modulates alternative splicing of pre-mRNA, involved in the physiopathology of muscle dystrophy. | 1.25 |
| RBM20 | RNA binding protein involved in familial dilated cardiomyopathy and is involved in alternative splicing of TTN. | 1.37 |
| TTN | Protein of striated muscle. | 1.53 |
| OBSCN | Proteins that include titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. | 1.50 |
| ADHFE1 | Hydroxyacid-oxoacid transhydrogenase which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues; involved in increased muscle mass in horses. | 1.58 |
| SLC25A33 | Pyrimidine Nucleotide Carrier which is associated with muscle wasting. | 0.82 |
| B-G | Leukocyte antigen. | 1.59 |
| Receptor for pain | ||
| P2RX4 | Purinoreceptor for ATP-gated ion channel, involved in pain reception in mouse. | 0.78 |
| Ion Channel | ||
| SCN5A | Integral membrane protein and voltage-gated sodium channel subunit. | 1.31 |
| DNA repair | ||
| EME2 | Involved in repairing DNA damage and maintaining genomic stability. | 0.65 |
MRPL28, Mitochondrial ribosomal protein L28; COQ6, Coenzyme Q6 homolog, monooxygenase; MCAT, Malonyl CoA:ACP acyltransferase; TBL1X, Transducin (beta)-like 1X-linked; ACP6, acid phosphatase 6; CYP39A1, Cytochrome P450, family 39, subfamily A, polypeptide 1; BTC, Betacellulin, ABHD2, Abhydrolase domain containing 2; EPS15, Epidermal growth factor receptor pathway substrate 15; MBNL2, Muscleblind-like 2 Drosophila; RBM20, RNA binding motif protein 20; TTN, Titin; OBSCN, Obscurin; ADHFE1, Alcohol dehydrogenase, iron containing, 1; SLC25A33, Carrier family 25, member 3; B-G, V-region-like B-G antigen-like; P2RX4, purinergic receptor P2X, ligand-4; SCN5A, sodium channel, voltage-gated, type V, alpha subunit, transcript variant 4; EME2, Essential Meiotic endonuclease 2 homolog 1