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. 2016 Apr 27;9:6. doi: 10.1186/s13069-016-0043-3

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© DiFazio et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Model that demonstrates the TGFβ-associated processes explores in this study. The red arrow around active disease represents processes that activate fibrotic cytokines, which then diminish during the early course of drug therapy (smaller arrows that are less red). αSMA and TGFβ drop, represented in green, while pSMAD-2/3 appears to rise and fall, in blue. Levels of collagen I do not change, shown in purple