Table 4.
Antibiotics and concentrations of extract | Bacterial strains and MIC values (μg/mL) | PBSS (%) | ||||||
---|---|---|---|---|---|---|---|---|
K. pneumoniae K24 | P. stuartii NAE16 | E. coli AG100 | E. aerogenes EA289 | P. aeruginosa PA124 | E. aerogenes CM64 | |||
TET | 0 | 64 | 64 | 16 | 8 | 16 | 32 | - |
MIC/2 | 64(1)I | 64(1)I | 8(2)S | 8(1)I | 16(1)I | 16(2)S | 33.33 | |
MIC /5 | 64(1)I | 64(1)I | 16(1)I | 8(1)I | 16(1)I | 16(2)S | 16.67 | |
NOR | 0 | ≥64 | 1 | ≤0.25 | - | 128 | 2(1)I | - |
MIC/2 | ≥64 | 1(1)I | ≤0.25 | - | 128 (1)I | 2(1)I | 0 | |
MIC /5 | ≥64 | 1(1)I | ≤0.25 | - | 128(1)I | 2(1)I | 0 | |
STR | 0 | 2 | 32 | ≥256 | 64 | 64 | 16 | - |
MIC/2 | 2(1)I | 32(1)I | ≥256 | 32(2)S | 64(1)I | 8(2)S | 16.67 | |
MIC /5 | 2(1)I | 32(1)I | ≥256 | 64(1)I | 64(1)I | 16(1)I | 0 | |
KAN | 0 | 8 | 8 | 8 | 32 | 64 | ≤2 | - |
MIC/2 | 8(1)I | 8(1)I | 4(2)S | 16(2)S | 64(1)I | ≤2 | 33.33 | |
MIC /5 | 8(1)I | 8(1)I | 8(1)I | 32(1)I | 64(1)I | ≤2 | 16.67 | |
CHL | 0 | 16 | 8 | 8 | 512 | 64 | 512 | - |
MIC/2 | 16(1)I | 4(2)S | 8(1)I | 512(1)I | 64(1)I | 512 | 16.67 | |
MIC /5 | 16(1)I | 8(1)I | 8(1)I | 512(1)I | 64(1)I | 512 | 0 | |
ERY | 0 | 128 | 16(1)I | 64 | 128 | 128 | 256 | - |
MIC/2 | 128(1)I | 16(1)I | 64(1)I | 128(1)I | 128(1)I | 128(2)S | 16.67 | |
MIC /5 | 128(1)I | 16(1)I | 64(1)I | 128(1)I | 128(1)I | 256(1)I | 0 | |
AMP | 0 | - | - | 128 | - | - | - | - |
MIC/2 | - | - | 256(2)I | - | - | - | 0 | |
MIC /5 | - | - | 256(2)I | - | - | - | 0 |
(-) : >256 μg/ml; (): fold decrease in MIC values of the antibiotics after association with plants extract; S: Synergy, I: Indifference; A: antagonism, Antibotics (CHL chloramphenicol, AMP ampicillin, KAN kanamycin, NOR norfloxacin, ERY erythromycin, TET tetracycline, STR streptomycin); PBSS percentage of bacteria strain on which synergism has been observed