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. 2016 May 3;11:43. doi: 10.1186/s13000-016-0493-3

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© Nakamura et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — a, b Histopathological specimens revealed lymphatic follicles (arrowhead) with an enlarged and hyperplastic germinal center. c, d The specimens were immunoreactive against both CD3 and CD20. e, f Immunohistochemical staining of IgG and IgG4 revealed a ratio of IgG4/IgG-positive plasma cells (arrowhead) of approximately 50 % and large quantities of IgG4 were noted in the germinal center