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. 2016 Apr 7;1(4):e83116. doi: 10.1172/jci.insight.83116

Figure 3. Vaccinia immunotherapy reverses lung fibrosis.

Figure 3

(A) Histological analysis of lungs 70 days following i.p. bleomycin (Bleo). H&E staining of lung sections at ×20 (left panels) and ×100 (right panels) magnification; Masson’s trichrome staining at ×100 magnification. (B) Total lung cells 70 days following i.p. Bleo. (C) Flow cytometric analysis of total lung CD4+ T cells, CD11b+, and GR1+ cells. (D) Intracellular cytokine analysis of total lung IFNG+, IL17+, and FoxP3+ CD4+ T cells. (E) Flow cytometric analysis of lung fibrocytes. (F) Total Lung collagen at either 42 or 70 days following i.p. Bleo. Error bars represent one standard error of the mean. Experiments were performed at 3 times with 10 mice per group. Significance determined by a paired Student’s t tests or 1-way ANOVA followed by Tukey’s test when indicated.