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. 2016 Apr 7;1(4):e83116. doi: 10.1172/jci.insight.83116

Figure 6. Vaccinia immunotherapy creates a lung niche of memory CD4+ T cells.

Figure 6

(A) Flow cytometric analysis of circulating (blood) vs. protected (lung niche) CD4+ T cells on day 70 following i.p. bleomycin (Bleo) with or without vaccinia vaccine treatment. (B) Percentage of memory (CD44+ CD62L+) marker expressing CD4+ T cells in the circulating and protected pool of i.p. Bleo-treated mice. (C) Flow cytometric plots of circulating (blood) vs. protected (lung niche) CD4+ T cells on day 14 from mice treated with i.p. PBS, i.p. vaccinia vaccine, or i.n. vaccinia vaccine. Error bars represent one standard deviation of the mean. Experiments were performed 3 times with 10 mice per group. Significance determined by 1-way ANOVA followed by Tukey’s test when indicated.