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. Author manuscript; available in PMC: 2016 Sep 7.
Published in final edited form as: Nature. 2016 Mar 7;531(7594):395–399. doi: 10.1038/nature17163

Extended Data Figure 5. Interactions of the nanobody and SecA with SecY.

Extended Data Figure 5

a, The nanobody binds to the plug and to the loop between TMs 3 and 4 (L3/4). b, The polypeptide crosslinking domain (PPXD; in yellow) of SecA interacts with the loop between TMs 8 and 9 of SecY (L8/9; in red), and the long helix of the helical scaffold domain (HSD; in blue) with the loop between TMs 2 and 3 (L2/3; in red). The loop between TMs 6 and 7 of SecY (L6/7; in red) does not seem to make strong contact with SecA. c, Two helices of the HSD interact with the C-terminal tail of SecY (C-tail; in red).