Fig. 5.

Motif analysis. The three most commonly identified sequence motifs of the top 500 FXR binding sites in the liver (top panel) and intestine (bottom panel) are shown according to MEME analysis. In the liver an IR1 was the most common sequence motif found. Two of the three motifs identified (left and right motif) in the liver showed the presence of a half nuclear receptor binding site at the 3′ end of the IR1. In the intestine, an IR1 (left motif) or an ER2 (middle motif) were motifs commonly found within the top 500 FXR binding sites. The motifs found in the intestine are arbitrarily aligned to match up with the sequence motifs in the liver to show sequence similarity. In the intestine, a half nuclear receptor binding site was also associated with the identified FXRRE either at the 5′ end (half-site 1) or at the 3′ end (half-site 2), depending on which motif is recognized as an FXRRE. E-values, a measure of significance, were between 3.8e-037 to 9.3e-085.