Table 3.
Pathways Enriched with FXR Binding 2 kb Upstream of Genes
| Tissue | Biological Process | Genes* | % Bound by FXR |
P Value | Bonferroni |
|---|---|---|---|---|---|
| Liver | Primary metabolic process | 92 | 93.9 | 1.70E-25 | 8.80E-22 |
| Cellular metabolic process | 88 | 89.8 | 1.90E-20 | 9.60E-17 | |
| Biosynthetic process | 38 | 38.8 | 7.60E-16 | 4.00E-12 | |
| Cellular biosynthetic process | 25 | 25.5 | 5.60E-09 | 2.90E-05 | |
| Nitrogen compound metabolic process | 25 | 25.5 | 4.90E-17 | 2.60E-13 | |
| Amine metabolic process | 24 | 24.5 | 1.40E-16 | 5.80E-13 | |
| Amino acid and derivative metabolic process | 24 | 24.5 | 3.80E-18 | 2.00E-14 | |
| Amino acid metabolic process | 23 | 23.5 | 3.20E-19 | 1.70E-15 | |
| Lipid biosynthetic process | 21 | 21.4 | 8.90E-17 | 5.80E-13 | |
| Steroid metabolic process | 18 | 18.4 | 7.50E-17 | 5.80E-13 | |
| Monosaccharide metabolic process | 11 | 11.2 | 3.80E-08 | 1.90E-04 | |
| Hexose metabolic process | 11 | 11.2 | 3.10E-08 | 1.60E-04 | |
| Sterol metabolic process | 11 | 11.2 | 4.50E-11 | 2.30E-07 | |
| Cholesterol metabolic process | 11 | 11.2 | 1.70E-11 | 8.80E-08 | |
| Glucose metabolic process | 10 | 10.2 | 2.80E-08 | 1.50E-04 | |
| Lipid catabolic process | 10 | 10.2 | 2.40E-08 | 1.20E-04 | |
| Fatty acid oxidation | 8 | 8.2 | 1.30E-10 | 7.00E-07 | |
| Steroid biosynthetic process | 7 | 7.1 | 6.30E-06 | 3.20E-02 | |
| Glycine, serine and threonine metabolism | 7 | 7.1 | 1.20E-04 | 2.30E-02 | |
| Isoprenoid metabolic process | 7 | 7.1 | 8.70E-08 | 4.50E-04 | |
| Pyruvate metabolic process | 7 | 7.1 | 8.40E-09 | 4.30E-05 | |
| Pyruvate metabolism | 6 | 6.1 | 5.60E-04 | 1.00E-01 | |
| Amino acid biosynthetic process | 6 | 6.1 | 7.80E-06 | 4.00E-02 | |
| Glycerol ether metabolic process | 6 | 6.1 | 1.30E-06 | 6.80E-03 | |
| Glycerolipid metabolic process | 6 | 6.1 | 1.10E-06 | 5.70E-03 | |
| Neutral lipid metabolic process | 6 | 6.1 | 1.10E-06 | 5.70E-03 | |
| Acylglycerol metabolic process | 6 | 6.1 | 9.20E-07 | 4.80E-03 | |
| Sterol transport | 6 | 6.1 | 9.50E-08 | 4.90E-04 | |
| Cholesterol transport | 6 | 6.1 | 7.00E-08 | 3.60E-04 | |
| Triacylglycerol metabolic process | 5 | 5.1 | 9.80E-06 | 4.90E-02 | |
| Gluconeogenesis | 5 | 5.1 | 6.50E-06 | 3.30E-02 | |
| Cholesterol homeostasis | 5 | 5.1 | 5.20E-06 | 2.70E-02 | |
| Lipid homeostasis | 5 | 5.1 | 5.20E-06 | 2.70E-02 | |
| Sterol homeostasis | 5 | 5.1 | 5.20E-06 | 2.70E-02 | |
| Intestine | Catalytic activity | 283 | 40.8 | 2.20E-16 | 6.00E-13 |
| Oxidoreductase activity | 64 | 9.2 | 2.30E-07 | 6.20E-04 | |
| Generation of precursor metabolites and energy | 46 | 6.6 | 2.40E-07 | 1.20E-03 | |
| Electron transport | 36 | 5.2 | 9.90E-06 | 5.00E-02 | |
| Iron ion binding | 30 | 4.3 | 3.10E-06 | 8.40E-03 | |
| Cofactor binding | 24 | 3.5 | 1.30E-07 | 3.40E-04 | |
| Vitamin binding | 19 | 2.7 | 1.70E-08 | 4.60E-05 | |
| Monooxygenase activity | 17 | 2.4 | 1.00E-05 | 2.80E-02 | |
| Complement and coagulation cascades | 14 | 2 | 9.70E-05 | 1.90E-02 | |
| Unspecific monooxygenase activity | 9 | 1.3 | 2.10E-05 | 5.50E-02 |
*
The number of genes bound by FXR in this pathway.