Figure 1. MRX-2843 is a dual MERTK and FLT3 TKI.

(A) Chemical structure of MRX-2843, with an enzymatic IC₅₀ of 1.3 nM for MERTK and 0.64 nM for FLT3 (B) Chemical structure of UNC2369, which lacks significant activity against MERTK (enzymatic IC₅₀ of 490 nM) or FLT3 (enzymatic IC₅₀ of 360 nM) and was used as a negative control in these studies. FLT3, FMS-like tyrosine kinase 3; TKI, tyrosine kinase inhibitor.