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. 2016 Apr 11;113(17):E2363–E2372. doi: 10.1073/pnas.1517066113

Fig. S1.

Fig. S1.

Alignment of the fifth transmembrane segments of different TRP proteins showing the mutations in this region that lead to GOF. Red and underlined amino acids show the GOF mutation sites that were identified in disease or random mutagenesis studies. In addition to the F604P in TRPP2 (indicated with asterisk) that was found in this study, mutations shown in the figure are as follows: F550I in Drosophila TRPC1 channel (fTRPC) (84); T635A in mouse TRPC3 (85); M581T in rat TRPV1 (86); L619P and L623P in rat TRPV4 (87); R616Q and V620I in human TRPV4 (88); R427P, C430P, C431P, and V432P in mouse TRPML1 (36); A419P in mouse TRPML3 (89, 90); and F380L in yeast TRPY1 (91). Adapted from ref. (35), with the TRPP2 sequence added.