Table 3.
Relationship between child genotype score and conduct problem trajectories, stratified by maternal drinking during pregnancy
| Genotype scorea Among children of nondrinking mothers | Genotype scorea Among children of mothers who drank moderately | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ≤2 | 3 | ≥4 | p value | ≤2 | 3 | ≥4 | OR (95% CI) | p value | ||
| N = 525 | N = 615 | N = 219 | OR (95% CI) | N = 875 | N = 937 | N = 373 | ||||
| Conduct problem trajectory | ||||||||||
| Low risk | 70.5% | 74.8% | 73.5% | 1.00 | 73.4% | 71.6% | 68.9% | 1.00 | ||
| Childhood‐limited | 12.4% | 9.6% | 9.6% | 0.83 (0.64–1.06) | .139 | 11.8% | 12.5% | 11.5% | 1.03 (0.87–1.24) | .720 |
| Adolescence‐onset | 8.8% | 7.8% | 8.7% | 0.95 (0.72–1.26) | .718 | 8.3% | 7.7% | 9.4% | 1.07 (0.86–1.32) | .547 |
| Early‐onset‐persistent | 8.8% | 7.8% | 8.7% | 0.94 (0.72–1.25) | .688 | 6.5% | 8.2% | 10.2% | 1.29 (1.04–1.60) | .020 |
% = column percent.
Each OR represents the increased odds per unit increase in genotype score of being in a conduct problem trajectory (early‐onset, childhood‐limited or adolescence‐onset) compared to being in the low‐risk trajectory. Two models were calculated using multinomial logistic regression, one for children of nondrinking mothers, one for children of mothers who drank moderately.
a
Total number of risk alleles in ADH1A rs2866151 rs975833, ADH1B rs4147536 and ADH7 rs28477.