Table 2.
Summary of the main characteristics of the animal models of clear cell and endometrioid ovarian cancer
| Model [ref] | Immunocompetent | Genetic modification needed | Genetically manipulable | Genes manipulated | Site of origin of tumour in mouse model |
|---|---|---|---|---|---|
| Mouse OEA model 51 | Yes | Yes | Yes | Kras, Pten | OEA probably from endometriosis‐like lesions on ovarian surface epithelium (glands but no stroma) |
| Mouse OCCA model 68 | Yes | Yes | Yes | Arid1a, Pik3ca | OCCA arose from ovarian surface epithelium |
| Mouse OEA model 69 | Yes | Yes | Yes | Arid1a, Pten | OEA arose from ovarian surface epithelium |
| Mouse OEA model 70 | Yes | No | Yes | Apc, Pten | OEA arose from ovarian surface epithelium |
| Mouse OEA model 71 | Yes | No | Yes | Apc, Pten, Trp53 | OEA arose from ovarian surface epithelium |