Figure 1.

Development plan performances for p ₀=0.15, p ₁=0.3, α = 0.0025, β = 0.36. The expected sample size; $\mathbb{E}\left(N\right|p_C,p_E)$, powerl; P(p _C,p _E), and ‘power per patient’; $P(p_C,p_E)/\mathbb{E}\left(N\right|p_C,p_E)$, of the six development plans, across the complete possible range of true response rates in the control (p _C) and treatment (p _E) arms is depicted. The dotted white line in the P(p _C,p _E) plots indicates the contour P(p _C,p _E) = α.