Table 3.
Body size at birth, childhood, early adulthood and risk of lymphoid malignancy
| Adjusted for age, year of birth, region, and socioeconomic status | Additionally adjusted for 4 factors,a but NOT recent BMI | Additionally adjusted for 4 factors,a AND recent BMI | ||
|---|---|---|---|---|
| cases | (RR, 95% gs‐CI) | (RR, 95% gs‐CI) | (RR, 95% gs‐CI) | |
| Birth weight | ||||
| <2.5 kg | 424 | 1.00 (0.91–1.10) | 1.00 (0.91–1.10) | 1.00 (0.91–1.10) |
| 2.5–2.9 kg | 600 | 1.00 (0.92–1.08) | 0.99 (0.92–1.08) | 1.00 (0.92–1.08) |
| 3.0–3.4 kg | 1103 | 1.02 (0.96–1.08) | 0.99 (0.94–1.05) | 1.00 (0.94–1.06) |
| 3.5–3.9 kg | 616 | 1.06 (0.98–1.15) | 1.03 (0.95–1.11) | 1.02 (0.94–1.11) |
| 4.0 kg or larger | 537 | 1.22 (1.12–1.33) | 1.16 (1.06–1.26) | 1.15 (1.05–1.25) |
| p=0.004 | p=0.05 | p=0.1 | ||
| Relative size at age 10 years | ||||
| Thinner | 1717 | 1.00 (0.95–1.05) | 1.00 (0.95–1.05) | 1.00 (0.95–1.05) |
| Average | 3149 | 1.08 (1.04–1.12) | 1.09 (1.05–1.13) | 1.08 (1.04–1.12) |
| Plumper | 899 | 1.14 (1.07–1.22) | 1.15 (1.08–1.23) | 1.10 (1.03–1.18) |
| p=0.003 | p=0.001 | p=0.01 | ||
| Relative size at age 20 years | ||||
| Small | 1472 | 1.00 (0.95–1.05) | 1.00 (0.95–1.05) | 1.00 (0.95–1.06) |
| Medium | 2122 | 1.08 (1.04–1.13) | 1.05 (1.01–1.10) | 1.04 (1.00–1.08) |
| Large | 2171 | 1.33 (1.28–1.39) | 1.25 (1.20–1.31) | 1.19 (1.14–1.25) |
| p<0.001 | p<0.001 | p<0.001 |
BMI: body mass index; gs‐CI: group–specific confidence interval; RR: relative risk
a
Additionally adjusted for height, smoking, exercise, and alcohol consumption.