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. 2016 Apr 28;7(4):e2209. doi: 10.1038/cddis.2016.102

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Sphere formation is dependent on CD95/CD95L signaling. (a–c) Sphere formation by freshly isolated cells from three patient tumor samples treated with DMSO (control), APG101 (APG), TMZ or a combination of both (n≥12 per conditions, overall comparison: one-way ANOVA, pairwise comparison: Tukey's multiple comparison test). (d–k) CD95L-ELISA for patient-derived cell culture supernatants (d–g) or lysates (h–k) treated with DMSO (Co) or TMZ (two sided t-test with Holm correction)