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. 2016 Apr 7;7(4):e2174. doi: 10.1038/cddis.2016.73

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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KCa3.1 inhibition reverts GCM-induced microglia polarization. (a) RT-PCR on mRNAs of microglia treated with NCM or GCM in the absence (C) or presence of TRAM-34 (T, 2.5 μM), analyzed for the expression of M2-like (arg1, ym1, fizz1, cd163 and cd206) and M1-like (cd86, tnfα, inos, il1β and il6) related genes. Data are expressed as fold increase and are the mean±S.E.M.; *P<0.05 versus NCM; ^#P<0.05 versus GCM/C by two-way ANOVA and paired t-test for inos; N=8. (b) NCM- and GCM-treated microglia in the absence (C) or presence of TRAM-34 (T, 2.5 μM), stained with phalloidin (green) and Hoechst (blue). Scale bar: 20 μm. Form factor values (calculated as reported in the Materials and Methods section) are shown in the graph and are the mean±S.E.M., *P<0.05 versus NCM; ^#P<0.05 versus GCM/C by two-way ANOVA; N=4