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. 2016 Apr 14;7(4):e2193. doi: 10.1038/cddis.2016.83

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The proportion of CD3⁺CD4⁻CD8⁻ double-negative T cells (DNT) was upregulated following ConA administration in C57BL/6 mice. DNT were significantly induced by ConA stimulation in a dose- ((a and b), n=3 in each group) and time- (c) dependent manner (n=4). The induced DNT (Gray histograms) highly expressed αβTCR, B220, CD44 and CXCR3, whereas no expression of CD4, CD8, CD19 and NK1.1 was observed. Mouse isotype Ig used as control (white histograms, d). Gene expression profile of ConA-induced DNT (e). **P<0.01, *P<0.05