Table 1.
Item | Treatmentb | Pooled SEM | Contrastc | |||||
---|---|---|---|---|---|---|---|---|
Control | LPS | LPS + Low GLP-2 | LPS + High GLP-2 | 1 | 2 | 3 | ||
Initial BW, kg | 6.78 | 6.82 | 6.82 | 6.78 | 0.068 | 0.824 | 0.980 | 0.844 |
Final BW, kg | 9.61 | 9.41 | 9.98 | 10.11 | 0.11 | 0.499 | 0.061 | 0.022 |
d 0 to 7 | ||||||||
ADFI, g/d | 320 | 321 | 320 | 312 | 7 | 0.966 | 0.943 | 0.691 |
ADG, g/d | 183 | 174 | 205 | 203 | 5 | 0.465 | 0.013 | 0.019 |
G:F | 0.574 | 0.543 | 0.645 | 0.656 | 0.012 | 0.237 | <0.001 | <0.001 |
d 7 to 14 | ||||||||
ADFI, g/d | 379 | 355 | 380 | 394 | 9 | 0.360 | 0.340 | 0.148 |
ADG, g/d | 221 | 195 | 245 | 272 | 10 | 0.306 | 0.052 | 0.004 |
G:F | 0.583 | 0.544 | 0.634 | 0.688 | 0.013 | 0.198 | 0.005 | <0.001 |
d 0 to 14 | ||||||||
ADFI, g/d | 350 | 338 | 350 | 353 | 7 | 0.558 | 0.552 | 0.468 |
ADG, g/d | 202 | 184 | 225 | 237 | 7 | 0.297 | 0.018 | 0.003 |
G:F | 0.579 | 0.545 | 0.640 | 0.674 | 0.012 | 0.196 | 0.001 | <0.001 |
aGLP-2 = Glucagon-like peptide 2; LPS = Escherichia coli lipopolysaccharide
bControl: non-challenged control; LPS: pigs injected with sterile PBS solution containing 0 nmol/kg BW human GLP-2; LPS + Low and LPS + High GLP-2: piglets injected with PBS solution containing h[Gly2]GLP-21-34 at doses of 2 and 10 nmol/kg BW per day for the first 7 d after weaning. The data were obtained before LPS challenge
cContrast: (1) control v. LPS; (2) LPS v. LPS + Low GLP-2; (3) LPS v. LPS + High GLP-2; Values are means of ten replicates