Table 2.
The effect of h[Gly2]GLP-21-34 on plasma GLP-2 concentrations in weaned piglets before LPS challengea (pg/mL)
| Item | Treatmentb | Pooled SEM | Contrastd | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Control | LPS | LPS + Low GLP-2 | LPS + High GLP-2 | 1 | 2 | 3 | |||
| d 0 | 199.8 | 202.1 | 200.7 | 201.6 | 1.7 | 0.646 | 0.773 | 0.921 | |
| d 7 | 169.4 | 164.2 | 179.9 | 195.2 | 2.2 | 0.120 | <0.001 | <0.001 | |
| d 14 | 195.1 | 190.6 | 210.4 | 230.1 | 3.1 | 0.397 | 0.001 | <0.001 | |
| Pooled SEM | 2.9 | 3.3 | 3.0 | 3.5 | -- | -- | -- | -- | |
| Contrastc | 1 | <0.001 | <0.001 | <0.001 | 0.522 | -- | -- | -- | |
| 2 | <0.001 | <0.001 | <0.001 | <0.001 | -- | -- | -- | ||
| 3 | 0.231 | 0.006 | 0.055 | <0.001 | -- | -- | -- | ||
aGLP-2 = Glucagon-like peptide 2; LPS = Escherichia coli lipopolysaccharide
bControl: non-challenged control; LPS: pigs injected with sterile PBS solution containing 0 nmol/kg BW human GLP-2; LPS + Low and LPS + High GLP-2: piglets injected with PBS solution containing h[Gly2]GLP-21-34 at doses of 2 and 10 nmol/kg BW per day for the first 7 d after weaning. The data were obtained before LPS challenge
cContrast: (1) 0 d v. 7 d; (2) 7 d v. 14 d; (3). 0 d v.14 d
dContrast: (1) control v. LPS; (2) LPS v. LPS + Low GLP-2; (3) LPS v. LPS + High GLP-2; Values are means of ten replicates