Table 4.
Specific genetic alterations in TP53 gene detected in the five SCLC PDXs
| PDX | TP53 alteration | COSMIC ID# | Remarks |
|---|---|---|---|
| TKO-001 | c.422G>A[p.Cys141Tyr] | COSM131470 | Missense mutation |
| TKO-002 | c.488A>G[p.Tyr163Cys] | COSM10808 | Listed in COSMIC and dbSNP (rs148924904), evidence in COSMIC for being somatic |
| TKO-003 | c.913A>T[p.Lys305Ter] | COSM43773 | Stop (Ter) Hemizygous, deletion of one copy |
| TKO-005 | c.488A>G[p.Tyr163Cys] | COSM10808 | Listed in COSMIC and dbSNP (rs148924904), evidence in COSMIC for being somatic |
| TKO-008 | c.892G>T[p.Glu298Ter] | COSM10710 | Stop (Ter) 80 % of reads |