Table 3.

Analyses of the discrimination power of HCL-32 and its sub-domains in screening BDs

	HCL-32 total	Active/elated	Irritable/risk-taking
BD1 vs Control
AUC (95 % CI)	0.56 (0.51–0.61)	0.52 (0.47–0.57)	0.67 (0.62–0.72)
optimal cut-off score	>19	≥12	>2
PPV (%)	38.87 (28.89–49.60)	29.72 (23.42–36.65)	37.96 (31.07–45.24)
NPV (%)	77.72 (72.22–81.52)	76.53 (70.50–81.86)	83.20 (77.77–87.76)
sensitivity (95 % CI)	0.32 (0.24–0.42)	0.52 (0.42–0.62)	0.65 (0.55–0.74)
specificity (95 % CI)	0.82 (0.77–0.86)	0.56 (0.50–0.62)	0.62 (0.56–0.67)
BD2 vs Control
AUC	0.64 (0.60–0.69)	0.54 (0.49–0.59)	0.75 (0.70–0.79)
optimal cut-off score	>21	>11	>2
PPV (%)	53.84 (43.54–71.23)	27.20 (22.06–32.84)	37.63 (30.82–44.81)
NPV (%)	81.31 (76.95–85.17)	83.27 (76.12–88.99)	88.50 (83.60–92.36)
sensitivity (95 % CI)	0.31 (0.22–0.40)	0.76 (0.66–0.83)	0.74 (0.64–0.82)
specificity (95 % CI)	0.93 (0.90–0.96)	0.37 (0.32–0.43)	0.62 (0.56–0.67)
BDs vs Control
AUC	0.60 (0.56–0.65)	0.51 (0.47–0.56)	0.71 (0.67–0.75)
optimal cut-off score	>19	>10	>2
PPV (%)	58.44 (49.66–66.83)	43.31 (38.28–48.46)	56.07 (49.94–62.07)
NPV (%)	64.57 (59.65–69.28)	63.82 (55.64–71.45)	73.99 (68.24–79.19)
sensitivity (95 % CI)	0.36 (0.30–0.43)	0.75 (0.68–0.80)	0.69 (0.62–0.75)
specificity (95 % CI)	0.82 (0.77–0.86)	0.31 (0.26–0.37)	0.62 (0.56–0.67)

Cut-off score with the highest Youden’s Index value

AUC the area under the curve of the receiver operating characteristic (ROC) curve, HCL-32 hypomania checklist 32, BD1 bipolar I disorder, BD2 bipolar II disorder, BDs bipolar disorders, PPV positive predictive value, NPV negative predictive value