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. 2016 May 4;17:323. doi: 10.1186/s12864-016-2671-9

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© Naraballobh et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Significant pathways altered by in-ovo thermal modifications; in (a) embryonic stage and (b) D35. DEGs associated with each comparison (treatment vs control) are separated into up-regulation (U) or down-regulation (D). Thermal modification treatments: increase (H) or decrease (L) incubation temperature during E7-10 (H10 and L10) or E10-13 (H13 and L13). Significant pathways (IPA defined) are grouped into eight major categories of interest; group (gr.)1 cell maintenance proliferation differentiation and replacement, gr.2 organismal organ and tissue development, gr.3 nutrient metabolism, gr.4 genetic information and nucleic acid processing, gr.5 molecular transport, gr.6 cell signaling and interaction, gr.7 small molecule biochemistry, and gr.8 response to stimuli and associated. The –log (BH p-value) associated with significant pathways are plotted in green (small) to red (large)