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. 2016 May 4;13:23. doi: 10.1186/s12989-016-0134-8

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© Davidson et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Fraction of deposited nCeO₂, amsCeO_2, and aSiO₂ particles over a 48 h exposure, using fibroblasts cultured in 24-well tissue culture plates in fibroblast growth medium. The Harvard in vitro dosimetry method was used to determine the fraction of nanoparticle delivered to cells as a function of time. Uncoated nCeO₂ settled slower than both amsCeO₂ and aSiO₂, with all nanoparticles achieving approximately 90 % deposition by 40 h post-administration to cells