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. 2016 May 4;13:23. doi: 10.1186/s12989-016-0134-8

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© Davidson et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — nCeO₂ particles localize within fibroblastic nodules. NHLFs were treated with 0.2 μg/cm² of the indicated nanoparticle for 48 h. Following the treatments, cells were fixed, stained, and mounted onto glass, laser cut slides. Enhanced darkfield microscopy using the CytoViva illumination system revealed that the nanoparticles (bright spots) are localized on and around the fibroblastic nodules, suggesting that the accumulated particles may play a role in the initiation or formation of the nodules