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. 2016 Apr 21;1(5):e85484. doi: 10.1172/jci.insight.85484

Figure 3. Loss of Nogo-A/B protected mice from left ventricle dilation and systolic contractile dysfunction following chronic pressure overload.

Figure 3

Serial echocardiographic analysis of WT and Nogo-A/B–deficient mice before and after transverse aortic constriction (TAC) surgery. (A) Left ventricle (LV) end-diastolic diameter (LVDd), (B) LV end systolic (LVDs) diameter, and (C) fractional shortening (FS) were measured at the indicated time points after TAC. n ≥ 15/group. (D) Representative images of 2-dimensional guided M-mode echocardiography of the LV of WT and Nogo-A/B–deficient mice at baseline and 3 months after TAC. Data are expressed as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 compared with WT. Statistical significance was determined by 2-way ANOVA followed by Tukey’s multiple comparison test.