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. 2016 Apr 18;126(5):1968–1977. doi: 10.1172/JCI84712

Figure 3. Sex environment affects a transplant model of cold renal IRI.

Figure 3

(A) Murine kidneys transplanted with an 8-hour period of cold ischemia from female donors into female recipients (F→F; n = 5) had superior renal function after native nephrectomy compared with that seen in male donor kidneys transplanted into female recipients (M→F; n = 5; P < 0.05, by 2-way ANOVA) and had a trend toward improved function compared with that of female donor kidneys transplanted into male recipients (F→M; n = 6) and male donor kidneys transplanted into male recipients (M→M; n = 6). CIT, cold ischemia time. (B) Renal fibrosis on Sirius red staining showed a trend toward increased fibrosis in the M→F cohort that was significant compared with the fibrosis observed in all other cohorts (P < 0.001, by 1-way ANOVA). Error bars indicate the mean ± SEM.