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. 2016 Apr 11;126(5):1885–1896. doi: 10.1172/JCI85086

Figure 3. Platelets are important mediators of tumor rebound growth after withdrawal of antiangiogenic therapy.

Figure 3

(A) Mean aggregate tumor weight of A2780 cell–induced tumors in mice receiving platelet transfusions or APA twice weekly. (B and C) Representative immunohistochemical staining for (B) Ki67 and (C) caspase-3 and their quantification in control tumors (black bars) and tumors transfused with platelets (gray bars) twice weekly. Scale bar: 50 μm. (D and E) Mean aggregate tumor weight in (D) A2780 cell– or (E) HeyA8 cell–induced i.p. tumors for each indicated treatment group. (A, D, and E) n = 8–10 mice per group. (B and C) Representative images from tumors of at least 5 mice per group. **P < 0.01, ***P < 0.001 (1-way ANOVA followed by a Tukey’s multiple comparison post-hoc test in A, D, and E; 2-tailed Student’s t test in B and C). Averaged data are presented as the mean ± SEM.