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. 2016 Apr 18;126(5):1926–1938. doi: 10.1172/JCI83551

Figure 1. Inactivation of Epo in FOXD1 stroma-derived cells results in severe anemia.

Figure 1

(A) PCR analysis of genomic brain (Br), liver (L), and kidney (K) DNA isolated from control (Epofl/fl Cre–) and Foxd1-Epo–/– (Epofl/fl Cre+) mutant mice. 2-lox denotes the nonrecombined conditional allele and 1-lox the recombined allele. (B) Values for hematocrit (Hct), hemoglobin (Hb), rbc counts, and reticulocyte production index (RPI) from individual control (Co) and Foxd1-Epo–/– (Epo–/–) mutant mice (n = 3 each). (C) Renal and hepatic Epo mRNA and serum EPO (sEPO) levels from control and Foxd1-Epo–/– mutant mice (n = 3). Data are represented as mean ± SEM; 2-tailed Student’s t test; *P < 0.05, **P < 0.01, ***P < 0.001 compared with control group.