Table 2.

Factors associated with the release of P-TEFb from 7SK snRNP.

Factors	Mechanisms	Reference
PP2B and PP1 α	Sequentially dephosphorylate 7SK snRNP and Cdk9	[16]
PPM1G	Recruited by NF-κB and Tat, and dephosphorylates Cdk9	[17]
Tat	Changes confirmation of 7SK RNA	[18]
HIC mRNA	Displaces 7SK RNA from 7SK snRNP by competition	[20]
SRSF1 and 2	Binds the exonic-splicing enhancer sequence in nascent mRNA	[21]
Calpain 2	Cleaves Mepce	[22]
JMJD6	Decaps 7SK RNA and destabilizes 7SK snRNP	[25]
AFF1	Promotes Tat’s extraction of P-TEFb from 7SK snRNP	[55]
PIP7S	Maintains 7SK snRNP integrity	[56]

PP2B: Protein Phosphatase 2B; PP1α: Protein Phosphatase 1 α; 7SK snRNP: 7SK small nuclear ribonucleoprotein; PPM1G: Protein Phosphatase, Mg²⁺/Mn²⁺ dependent, 1G; NF-κB: Nuclear Factor-κB; Tat: Tyrosine aminotransferase; HIC: Human I-mfa domain containing protein; SRSF: Serine/Arginine-Rich Splicing Factor; JMJD6: Jumonji C-Domain-Containing Protein 6; AFF1: AF4/FMR2 Family Member 1; P-TEFb: Positive Transcription Elongation Factor b; PIP7S: P-TEFb-Interaction Protein for 7SK Stability