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. 2016 May 3;15:73. doi: 10.1186/s12934-016-0470-2

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© Beckers et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Genetic engineering targets towards improved PHA production in P. putida as predicted by an elementary flux mode-based correlation strategy (Flux Design). Red arrows represent reactions that are negatively correlated with PHA production and are therefore attenuation targets, whereas green arrows indicate positive correlation and thus overexpression targets. On the right, a priority ranking of all targets is given