Fig. 1.

Androgen mediated AR inhibition of the growth of human prostate epithelial cells (PrECs) and PrEC-hTERT cells in response to AR stimulation using physiologic levels of the synthetic androgen R1881 (i.e., 1nM). Expression and ligand activation of AR in both PrEC-LV-AR and PrEC-hTERT-LV-AR cells results in a significant growth suppression over a 1-week observation period, which is inhibited by co-administration of the anti-androgen Casodex (10 μM). An AR DNA-binding mutant (A573D) failed to inhibit growth when ligand-activated [* indicates a P-value < 0.05].