Skip to main content
. Author manuscript; available in PMC: 2017 Jun 21.
Published in final edited form as: Neuroscience. 2016 Apr 4;326:158–169. doi: 10.1016/j.neuroscience.2016.03.061

Figure 1. Mice with selective AMPKα1 deletion had mechanical allodynia and enhanced spinal glutamatergic synaptic activities in the spinal dorsal horn.

Figure 1

(A) shows that mechanical thresholds of hind paw withdrawal responses were significantly lower in AMPKα1 knockout mice than AMPKα1 littermate controls. (B) shows representative recordings of mEPSCs recorded from spinal superficial dorsal horn neurons of spinal slices obtained from AMPKα1 littermate controls (upper trace) and AMPKα1 knockout mice (lower trace). Bar graphs (C) show the mean (+ S.E.) amplitude and frequency obtained from AMPKα1 littermate controls and AMPKα1 knockout mice. ***, p < 0.001.