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. Author manuscript; available in PMC: 2016 May 4.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2011 Jan 24;46(2):118–136. doi: 10.3109/10409238.2010.541420

Figure 1.

Figure 1

Theoretical model of APC/C ubiquitination pathway. The four APC/C modules (Catalytic=Apc2, Apc11; Scaffold = Apc1, Apc4, Apc5; TPR=Apc3, Apc6, Apc8, Cdc26, Apc10, and species-specific subunits; and Activator=Cdc20 family member) are labeled. El = Ub-activating enzyme, E2 = Ub-conjugating enzyme, IR = IR motif in Cdc20 family members, C-box= conserved motif in Cdc20 family members, degrons=APC/C degradation motifs (e.g., D box, KEN box), DUB = deubiquitinating enzyme, * indicates elongation E2.