Table 1.
Nomenclature of APC/C components and other proteins across species.
| S. pombe | kDa | S. cerevisiae | kDa | D. melanogaster | kDa | H. sapiens | kDa | Domain |
|---|---|---|---|---|---|---|---|---|
| APC/C subunits | ||||||||
| Cut4 | 165 | Apc1 | 196 | Shattered A/B | 227/56 | Apc1 | 217 | PC repeats |
| Apc2 | 81 | Apc2 | 100 | Morula | 92 | Apc2 | 94 | Cullin-like |
| Nuc2* | 53 | Cdc27 | 79 | Makos | 101 | Apc3 | 92 | TPR repeats |
| Lid1 | 76 | Apc4 | 85 | Apc4 | 87 | Apc4 | 92 | |
| Apc5 | 83 | Apc5 | 75 | Ida A/B | 89/81 | Apc5 | 85 | TPR repeats |
| Cut9* | 76 | Cdc16 | 95 | Cdc16 | 82 | Apc6 | 72 | TPR repeats |
| — | — | Apc7A/B | 60/70 | Apc7 | 63 | TPR repeats | ||
| Cut23* | 60 | Cdc23 | 79 | Cdc23 | 78 | Apc8 | 69 | TPR repeats |
| — | Apc9 | 31 | — | — | ||||
| Apc10 | 22 | Doc1 | 33 | Apc10 | 22 | Apc10 | 21 | |
| Apc11 | 11 | Apc11 | 19 | Lemming | 10 | Apc11 | 10 | RING domain |
| Hcn1 | 9 | Cdc26 | 14 | — | Cdc26 | 10 | ||
| Apc13 | 16 | Swm1 | 19 | — | Apcl3 | 8 | ||
| Apc14 | 12 | — | — | — | ||||
| Apc15 | 16 | Mnd2 | 43 | — | — | |||
| — | — | — | Apc16 | 12 | ||||
| Ubiquitin conjugating enzymes | ||||||||
| Ubc11 | 20 | Ubc11 | 18 | vihar/UbcH10 | 20 | UbcH10/Ube2C | 20 | E2 |
| — | — | Ube2S | 23 | Ube2S | 24 | E2 | ||
| Ubc4 | 16 | Ubc4/Ubc5 | 16 | effete/UbcD1 | 17 | UbcH5 | 17 | E2 |
| Ubc1 | 24 | Ubc1 | 24 | Ube2K | 22 | Ube2K/E2-25K | 22 | E2 |
| Critical yeast substrates | ||||||||
| Cdc13 | 56 | Clb2 | 56 | cyclin B | 60 | cyclin B | 48 | cyclin box |
| Cut2 | 33 | Pds1 | 42 | Pirn | 58 | securin | 22 | securin |
*
Denotes two copies of subunit present in each Schizosaccharomyces pombe APC/C complex (Ohi et al. 2007). — Denotes that subunit has not been identified in this species. Proteins listed in the same row indicate homologs.