Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2016 May 4.

Published in final edited form as: J Med Chem. 2015 Dec 16;59(1):206–218. doi: 10.1021/acs.jmedchem.5b01268

Scheme 1a — ^aReagents and conditions: (a) tert-butyl-1,3-diisopropylisourea, CH₂Cl₂, rt, 3 d; (b) carbonyldiimidazole, CH₂Cl₂, rt, 1 h; (c) l-glutamic acid di-tert-butyl ester, neat, 45 °C, 2 d; (d) TFA/CH₂Cl₂ (1/1), rt, 2 h; (e) N-succinimidyl-4-fluorobenzoate or N-succinimidyl-4-[¹⁸F]fluorobenzoate, Et₃N, DMSO, rt, 2 h; (f) N-succinimidyl-4-iodobenzoate or N-succinimidyl-4-[¹²⁵l]iodobenzoate, diisopropylethylamine, DMSO rt, 1 h.