Table 1.
Best-fitting parameters describing the voltage-dependence of charge movement.
Qmax (nC µF−1) | VQ1/2 (mV) | K | |
---|---|---|---|
WT (n = 13) | 30 ± 8 | −14 ± 2.2 | 16 ± 1.5 |
DKO | 35 ±11 | −24±1.7 | 14 ± 1.9 |
(n = 15) | (P = 0.724) | (P = 0.001) | (P = 0.426) |
Data points were fitted to a Boltzmann equation of the form: Qon = Qmax/[1 + exp(VQ1/2 − Vm)/K], where Qmax is the maximum charge, Vm is the membrane potential, VQ1/2 is the charge movement half-activation potential and K is the steepness of the curve as described in ref. 27. The number of FDB fibres from three to four mice is between parentheses. Results are expressed as the mean ± s.e.m. Statistical significance was assessed using Student’s t-test. The α-level was set at P=0.05.