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. 2016 Feb 23;6(5):1227–1237. doi: 10.1534/g3.116.027300

Figure 6.

Figure 6

The 3′UTR of lin-14 is required for modulation of lin-14 gain-of-function phenotypes by stau-1 mutation. (A) Diagrams of C-terminal end of lin-14 gene in wild type, lin-14(n719), and lin-14(n355n679). The black boxes represent exons and the white boxes represent 3′UTR. The dotted box indicates the region of 3′UTR deleted in lin-14(n355n679). The predicated lin-4 family (green lines) and let-7 family (red lines) target sites are indicated; the target site predication was obtained from TargetScan (Lewis et al. 2005; Jan et al. 2011). (B) Adult alae phenotype of lin-4(e912); lin-14(n179) and lin-4(e912); lin-14(n179) stau-1(tm2266) animals. (C) Adult alae phenotype of lin-14(n355n679) and lin-14(n355n679) stau-1(tm2266) animals. *** P < 0.001; N.S., not significant (chi-square test for adult alae phenotype and two-tailed t-test for seam cell phenotype).