Table 6. The least-squares regressions of frequencies of individuals bearing the reduced networks 70_4R1 and 65_2R4 in our data set and in the HapMap data set.
Network/SNP | Dataset | Genes | Intercept | Slope | Quadratic Term | R2 |
---|---|---|---|---|---|---|
70_4R1 | Ours | VDR | 0.600 | 0.0106* | –0.0007* | 0.74 |
70_4R1 – Af | Ours | VDR | 0.854 | n.s. | n.s. | 0.18 |
70_4R1 | HapMap | VDR | 0.215 | 0.0148** | n.s. | 0.76 |
70_4R1 – Af | HapMap | VDR | 0.633 | n.s. | n.s. | 0.51 |
65_2R4 | Ours | VDR, MC1R, SLC24A5 | 0.484 | 0.0129** | –0.0007** | 0.85 |
65_2R4 – Af | Ours | VDR, MC1R, SLC24A5 | 0.698 | 0.0042* | n.s. | 0.54 |
65_2R4 | HapMap | VDR, MC1R, SLC24A5 | 0.021 | n.s. | n.s. | 0.48 |
65_2R4 – As | HapMap | VDR, MC1R, SLC24A5 | 0.046 | 0.0183** | n.s. | 0.90 |
65_2R4 – As | All | VDR, MC1R, SLC24A5 | 0.271 | 0.0189*** | –0.0005** | 0.89 |
65_2R4 – Af – As | All | VDR, MC1R, SLC24A5 | 0.693 | 0.0044** | n.s. | 0.65 |
Significant with P ≤ 0.05, ** significant with P ≤ 0.01, *** significant with P ≤ 0.001. SNP, single nucleotide polymorphism; n.s., not significant; – Af, the sub-Saharan populations have been excluded; – As, the Chinese and Japanese populations have been excluded.